Nanosized silica particles for chiral drug separation

The current work addresses the urgent need of novel stationary phases for rapid enantionseparation, and it complements and supports the projects by the PI in the synthesis and application of nanoparticles for achiral and chiral drug separation. The emphasis of this work lies on nanoparticle synthesi...

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Main Author: Tan, Timothy Thatt Yang.
Other Authors: School of Chemical and Biomedical Engineering
Format: Research Report
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10356/42336
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-423362023-03-03T15:30:51Z Nanosized silica particles for chiral drug separation Tan, Timothy Thatt Yang. School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology The current work addresses the urgent need of novel stationary phases for rapid enantionseparation, and it complements and supports the projects by the PI in the synthesis and application of nanoparticles for achiral and chiral drug separation. The emphasis of this work lies on nanoparticle synthesis and functionalization. This objective has been met. Nanoparticles of various sizes and porosity have been successfully synthesized, C18-functionalized and chiral-functionalized via two different methods using the small equipment support obtained from the current work. Preliminary chromatographic evaluation has also been carried out using ultra performance liquid chromatography (UPLC) and supercritical fluid chromatography (SFC), but will be discussed in other reports. The chiral compounds can be separated but future work needs to be done to fine-tune the nanoparticles properties to optimize separation efficiencies. We intend to vary particles porosity or surface functional group loading in order to optimize the separation resolution. Small equipment procured from this work has helped the specific tailoring of nanoparticles of desired morphology and porosity for the generation of chiral stationary phase. Two publications, 1 accepted and 1 submitted, have been produced from this work. 2 more publications will ensue. The creation of silica nanoparticles for rapid chiral and achiral separation will open up new areas in separation technologies. RG114/06 2010-11-03T04:21:51Z 2010-11-03T04:21:51Z 2008 2008 Research Report http://hdl.handle.net/10356/42336 en 15 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology
spellingShingle DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology
Tan, Timothy Thatt Yang.
Nanosized silica particles for chiral drug separation
description The current work addresses the urgent need of novel stationary phases for rapid enantionseparation, and it complements and supports the projects by the PI in the synthesis and application of nanoparticles for achiral and chiral drug separation. The emphasis of this work lies on nanoparticle synthesis and functionalization. This objective has been met. Nanoparticles of various sizes and porosity have been successfully synthesized, C18-functionalized and chiral-functionalized via two different methods using the small equipment support obtained from the current work. Preliminary chromatographic evaluation has also been carried out using ultra performance liquid chromatography (UPLC) and supercritical fluid chromatography (SFC), but will be discussed in other reports. The chiral compounds can be separated but future work needs to be done to fine-tune the nanoparticles properties to optimize separation efficiencies. We intend to vary particles porosity or surface functional group loading in order to optimize the separation resolution. Small equipment procured from this work has helped the specific tailoring of nanoparticles of desired morphology and porosity for the generation of chiral stationary phase. Two publications, 1 accepted and 1 submitted, have been produced from this work. 2 more publications will ensue. The creation of silica nanoparticles for rapid chiral and achiral separation will open up new areas in separation technologies.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Tan, Timothy Thatt Yang.
format Research Report
author Tan, Timothy Thatt Yang.
author_sort Tan, Timothy Thatt Yang.
title Nanosized silica particles for chiral drug separation
title_short Nanosized silica particles for chiral drug separation
title_full Nanosized silica particles for chiral drug separation
title_fullStr Nanosized silica particles for chiral drug separation
title_full_unstemmed Nanosized silica particles for chiral drug separation
title_sort nanosized silica particles for chiral drug separation
publishDate 2010
url http://hdl.handle.net/10356/42336
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