Design of novel organocatalysts for asymmetric carbon-carbon bonds formation reactions

• Main Author: Teo, Yong Chua
• Other Authors: National Institute of Education
• Format: Research Report
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• Online Access: http://hdl.handle.net/10356/42739
• Institution: Nanyang Technological University

In this project, a siloxy serine organocatalyst was developed for the asymmetric aldol reaction and Mannich reactions using either water or ionic liquids as the reaction medium. The synthesis of the organocatalyst using Z-protected serine amino acid was economical and operationally simple. In...