Proteomics and metabolomics analysis of cellular response to anti-coagulating drug warfarin
The combination of pharmaco-proteomics and metabolomics study has identified potential serum dosage marker for the anti-coagulating drug warfarin, which is with a narrow therapeutic index. In vitro studies have also investigated on the enantiomeric differences in drug action mechanism. Our findings...
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sg-ntu-dr.10356-428952023-03-03T16:02:22Z Proteomics and metabolomics analysis of cellular response to anti-coagulating drug warfarin Bai, Jing Balram Chowbay Chen Wei Ning, William School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Biotechnology The combination of pharmaco-proteomics and metabolomics study has identified potential serum dosage marker for the anti-coagulating drug warfarin, which is with a narrow therapeutic index. In vitro studies have also investigated on the enantiomeric differences in drug action mechanism. Our findings provided molecular evidence on warfarin-cell interaction which may shed new lights on future improvement of warfarin therapy. DOCTOR OF PHILOSOPHY (SCBE) 2011-02-17T06:25:19Z 2011-02-17T06:25:19Z 2011 2011 Thesis https://hdl.handle.net/10356/42895 10.32657/10356/42895 en 201 p. application/pdf |
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DRNTU::Engineering::Chemical engineering::Biotechnology |
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DRNTU::Engineering::Chemical engineering::Biotechnology Bai, Jing Proteomics and metabolomics analysis of cellular response to anti-coagulating drug warfarin |
| description |
The combination of pharmaco-proteomics and metabolomics study has identified potential serum dosage marker for the anti-coagulating drug warfarin, which is with a narrow therapeutic index. In vitro studies have also investigated on the enantiomeric differences in drug action mechanism. Our findings provided molecular evidence on warfarin-cell interaction which may shed new lights on future improvement of warfarin therapy. |
| author2 |
Balram Chowbay |
| author_facet |
Balram Chowbay Bai, Jing |
| format |
Theses and Dissertations |
| author |
Bai, Jing |
| author_sort |
Bai, Jing |
| title |
Proteomics and metabolomics analysis of cellular response to anti-coagulating drug warfarin |
| title_short |
Proteomics and metabolomics analysis of cellular response to anti-coagulating drug warfarin |
| title_full |
Proteomics and metabolomics analysis of cellular response to anti-coagulating drug warfarin |
| title_fullStr |
Proteomics and metabolomics analysis of cellular response to anti-coagulating drug warfarin |
| title_full_unstemmed |
Proteomics and metabolomics analysis of cellular response to anti-coagulating drug warfarin |
| title_sort |
proteomics and metabolomics analysis of cellular response to anti-coagulating drug warfarin |
| publishDate |
2011 |
| url |
https://hdl.handle.net/10356/42895 |
| _version_ |
1759855450691469312 |