Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications

Layer-by-layer (LbL) self-assembled weak polyelectrolyte-based multilayered films have shown superior tunability and versatility to other polyelectrolyte multilayers. Previous works have focused primarily on the assembly of linearly grown synthetic weak polyelectrolyte multilayers. Further investiga...

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Main Author: Yuan, Weiyong
Other Authors: Li Changming
Format: Theses and Dissertations
Language:English
Published: 2011
Subjects:
Online Access:https://hdl.handle.net/10356/43517
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-435172023-03-03T16:00:15Z Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications Yuan, Weiyong Li Changming School of Chemical and Biomedical Engineering Centre for Advanced Bionanosystems DRNTU::Science::Medicine::Optical instruments Layer-by-layer (LbL) self-assembled weak polyelectrolyte-based multilayered films have shown superior tunability and versatility to other polyelectrolyte multilayers. Previous works have focused primarily on the assembly of linearly grown synthetic weak polyelectrolyte multilayers. Further investigation is warranted of weak polyelectrolyte-based self-assembly systems such as natural weak polyelectrolyte multilayers, nanoparticle-participated weak polyelectrolyte multilayers, and exponentially grown multilayers, their unique properties, and novel applications. In particular, in this PhD research project, a chitosan/alginate multilayer film was constructed via LbL self-assembly. The surface composition of the self-assembled multilayer film can be tailored through pH adjustment during the assembly process. The loading capacity of the antibody on the multilayered film and the binding activity of the antigen to the immobilized antibody can be well-tuned by pH control. This work can provide more scientific insight into the interaction between protein and polymer matrix and render a novel, simple approach to build high-performance biointerfaces through pH control for potential applications of highly sensitive immunosensors. DOCTOR OF PHILOSOPHY (SCBE) 2011-03-16T03:00:25Z 2011-03-16T03:00:25Z 2010 2010 Thesis Yuan, W. Y. (2010). Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/43517 10.32657/10356/43517 en 160 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Medicine::Optical instruments
spellingShingle DRNTU::Science::Medicine::Optical instruments
Yuan, Weiyong
Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications
description Layer-by-layer (LbL) self-assembled weak polyelectrolyte-based multilayered films have shown superior tunability and versatility to other polyelectrolyte multilayers. Previous works have focused primarily on the assembly of linearly grown synthetic weak polyelectrolyte multilayers. Further investigation is warranted of weak polyelectrolyte-based self-assembly systems such as natural weak polyelectrolyte multilayers, nanoparticle-participated weak polyelectrolyte multilayers, and exponentially grown multilayers, their unique properties, and novel applications. In particular, in this PhD research project, a chitosan/alginate multilayer film was constructed via LbL self-assembly. The surface composition of the self-assembled multilayer film can be tailored through pH adjustment during the assembly process. The loading capacity of the antibody on the multilayered film and the binding activity of the antigen to the immobilized antibody can be well-tuned by pH control. This work can provide more scientific insight into the interaction between protein and polymer matrix and render a novel, simple approach to build high-performance biointerfaces through pH control for potential applications of highly sensitive immunosensors.
author2 Li Changming
author_facet Li Changming
Yuan, Weiyong
format Theses and Dissertations
author Yuan, Weiyong
author_sort Yuan, Weiyong
title Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications
title_short Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications
title_full Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications
title_fullStr Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications
title_full_unstemmed Layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications
title_sort layer-by-layer self-assembled weak polyelectrolyte-based novel multilayered film : fabrication, unique properties and applications
publishDate 2011
url https://hdl.handle.net/10356/43517
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