Synthesis and characterisation of PEGDA-based hydrogels crosslinked with pentaerythritol tetrakis (3-Mercaptopropionate)

PEGDA-based hydrogels have been synthesised successfully by photopolymerisation and Michael-type addition reaction. Before the hydrogel is prepared, degree of acrylation is determined by 1H NMR characterisation. Photo-crosslinked hydrogels has been characterised by FTIR and show successful thiol-lin...

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Main Author: Toh, Jia Ban.
Other Authors: Marc Jean Medard Abadie
Format: Final Year Project
Language:English
Published: 2011
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Online Access:http://hdl.handle.net/10356/44027
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-440272023-03-04T15:40:01Z Synthesis and characterisation of PEGDA-based hydrogels crosslinked with pentaerythritol tetrakis (3-Mercaptopropionate) Toh, Jia Ban. Marc Jean Medard Abadie School of Materials Science and Engineering DRNTU::Engineering::Materials::Biomaterials PEGDA-based hydrogels have been synthesised successfully by photopolymerisation and Michael-type addition reaction. Before the hydrogel is prepared, degree of acrylation is determined by 1H NMR characterisation. Photo-crosslinked hydrogels has been characterised by FTIR and show successful thiol-linkage with the acrylate moieties. Selected PEGDA-based hydrogels have been put through Instron tensile and cyclic tests, and show highly elastic behaviour. The rheometry test reaffirmed the high elastic behaviour of selected PEGDA-based hydrogels through its corresponding high storage moduli for PEGDA macromers synthesized from PEG of Mw 8000 Da and 10000 Da. Equilibrium swelling test indicates the high water content and swelling ratio of photo-crosslinked hydrogels synthesized with PEGDA macromers with high degree of acrylation. Similar trend is found in Michael-type addition crosslinked hydrogels synthesized from PEG of Mw 4000 Da, 8000 Da and 10000 Da. In addition, higher wt% concentration of PEGDA involved in the preparation of Michael-type addition crosslinked hydrogels indicate better rheological property in terms of higher storage moduli. Equilibrium swelling test is performed to determine the composition of the three types of water existing in hydrogels. During degradation test, unexpected mass loss behaviour is observed in photo-crosslinked PEGDA-based hydrogels with high composition of non-freezing water indicated quantitatively by DSC test. Bachelor of Engineering (Materials Engineering) 2011-05-19T06:40:46Z 2011-05-19T06:40:46Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/44027 en Nanyang Technological University 48 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials::Biomaterials
spellingShingle DRNTU::Engineering::Materials::Biomaterials
Toh, Jia Ban.
Synthesis and characterisation of PEGDA-based hydrogels crosslinked with pentaerythritol tetrakis (3-Mercaptopropionate)
description PEGDA-based hydrogels have been synthesised successfully by photopolymerisation and Michael-type addition reaction. Before the hydrogel is prepared, degree of acrylation is determined by 1H NMR characterisation. Photo-crosslinked hydrogels has been characterised by FTIR and show successful thiol-linkage with the acrylate moieties. Selected PEGDA-based hydrogels have been put through Instron tensile and cyclic tests, and show highly elastic behaviour. The rheometry test reaffirmed the high elastic behaviour of selected PEGDA-based hydrogels through its corresponding high storage moduli for PEGDA macromers synthesized from PEG of Mw 8000 Da and 10000 Da. Equilibrium swelling test indicates the high water content and swelling ratio of photo-crosslinked hydrogels synthesized with PEGDA macromers with high degree of acrylation. Similar trend is found in Michael-type addition crosslinked hydrogels synthesized from PEG of Mw 4000 Da, 8000 Da and 10000 Da. In addition, higher wt% concentration of PEGDA involved in the preparation of Michael-type addition crosslinked hydrogels indicate better rheological property in terms of higher storage moduli. Equilibrium swelling test is performed to determine the composition of the three types of water existing in hydrogels. During degradation test, unexpected mass loss behaviour is observed in photo-crosslinked PEGDA-based hydrogels with high composition of non-freezing water indicated quantitatively by DSC test.
author2 Marc Jean Medard Abadie
author_facet Marc Jean Medard Abadie
Toh, Jia Ban.
format Final Year Project
author Toh, Jia Ban.
author_sort Toh, Jia Ban.
title Synthesis and characterisation of PEGDA-based hydrogels crosslinked with pentaerythritol tetrakis (3-Mercaptopropionate)
title_short Synthesis and characterisation of PEGDA-based hydrogels crosslinked with pentaerythritol tetrakis (3-Mercaptopropionate)
title_full Synthesis and characterisation of PEGDA-based hydrogels crosslinked with pentaerythritol tetrakis (3-Mercaptopropionate)
title_fullStr Synthesis and characterisation of PEGDA-based hydrogels crosslinked with pentaerythritol tetrakis (3-Mercaptopropionate)
title_full_unstemmed Synthesis and characterisation of PEGDA-based hydrogels crosslinked with pentaerythritol tetrakis (3-Mercaptopropionate)
title_sort synthesis and characterisation of pegda-based hydrogels crosslinked with pentaerythritol tetrakis (3-mercaptopropionate)
publishDate 2011
url http://hdl.handle.net/10356/44027
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