Healing wounds with hair

The skin is the first barrier that protects the human body from the external environment and hence it is important to explore potential wound dressings to improve wound healing on severe skin wounds. Tissue engineered scaffolds can act as an effective platform for cell adhesion and proliferation to...

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Main Author: Sow, Wan Ting.
Other Authors: School of Materials Science and Engineering
Format: Final Year Project
Language:English
Published: 2011
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Online Access:http://hdl.handle.net/10356/44300
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-443002023-03-04T15:36:16Z Healing wounds with hair Sow, Wan Ting. School of Materials Science and Engineering Asst Prof Ng Kee Woei DRNTU::Engineering::Materials::Biomaterials The skin is the first barrier that protects the human body from the external environment and hence it is important to explore potential wound dressings to improve wound healing on severe skin wounds. Tissue engineered scaffolds can act as an effective platform for cell adhesion and proliferation to promote wound healing. Hence keratin emerges as an attractive biological material for such scaffold as it is the main cytoskeleton protein found in the epidermis of the skin. Besides, electrospinning has been identified as a cost effective and scalable technique to produce nanoscale fibers for biomaterial scaffolds. Hence, in this project, electrospinning of keratin extracted from human hair is being explored. To facilitate the electrospinning of keratin, a small amount of poly (ethylene oxide) (PEO) was added into the keratin solution for electrospinning. A variety of solutions with different keratin/PEO concentrations were electrospun and comparisons on the morphologies of the fibers were made using the scanning electron microscopy. The best sample was characterised by various techniques such as fourier-transformed infra red spectroscopy, differential scanning calorimetry and thermogravimetric analysis. Electrospinning of 30wt% keratin and 0.5wt% PEO solution has resulted in a good deposition of fibers accumulated into a fibrous mat. The average diameter of the fibers electrospun was 330 nm and the properties of the fibrous mat followed closely to the properties of the extracted keratin. Therefore, electrospinning of keratin/PEO solution provides potentially useful option to fabricate 3-dimensional scaffolds and the idea of adding PEO to keratin opens up an appealing area in exploring the self assembly of keratin. Bachelor of Engineering (Materials Engineering) 2011-06-01T01:07:12Z 2011-06-01T01:07:12Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/44300 en Nanyang Technological University 48 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials::Biomaterials
spellingShingle DRNTU::Engineering::Materials::Biomaterials
Sow, Wan Ting.
Healing wounds with hair
description The skin is the first barrier that protects the human body from the external environment and hence it is important to explore potential wound dressings to improve wound healing on severe skin wounds. Tissue engineered scaffolds can act as an effective platform for cell adhesion and proliferation to promote wound healing. Hence keratin emerges as an attractive biological material for such scaffold as it is the main cytoskeleton protein found in the epidermis of the skin. Besides, electrospinning has been identified as a cost effective and scalable technique to produce nanoscale fibers for biomaterial scaffolds. Hence, in this project, electrospinning of keratin extracted from human hair is being explored. To facilitate the electrospinning of keratin, a small amount of poly (ethylene oxide) (PEO) was added into the keratin solution for electrospinning. A variety of solutions with different keratin/PEO concentrations were electrospun and comparisons on the morphologies of the fibers were made using the scanning electron microscopy. The best sample was characterised by various techniques such as fourier-transformed infra red spectroscopy, differential scanning calorimetry and thermogravimetric analysis. Electrospinning of 30wt% keratin and 0.5wt% PEO solution has resulted in a good deposition of fibers accumulated into a fibrous mat. The average diameter of the fibers electrospun was 330 nm and the properties of the fibrous mat followed closely to the properties of the extracted keratin. Therefore, electrospinning of keratin/PEO solution provides potentially useful option to fabricate 3-dimensional scaffolds and the idea of adding PEO to keratin opens up an appealing area in exploring the self assembly of keratin.
author2 School of Materials Science and Engineering
author_facet School of Materials Science and Engineering
Sow, Wan Ting.
format Final Year Project
author Sow, Wan Ting.
author_sort Sow, Wan Ting.
title Healing wounds with hair
title_short Healing wounds with hair
title_full Healing wounds with hair
title_fullStr Healing wounds with hair
title_full_unstemmed Healing wounds with hair
title_sort healing wounds with hair
publishDate 2011
url http://hdl.handle.net/10356/44300
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