Heparin potentiates TGF-β1-mediated phosphorylation of SMAD2 during chondrogenesis.

• Main Author: Liew, Pui Khuan.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/44748
• Institution: Nanyang Technological University

Adult mesenchymal stem cells (MSCs) hold great potential in regenerative medicine for treatment of joint diseases such as osteoarthritis (OA). A novel treatment strategy involving the administration of exogenous glycosaminoglycans, specifically heparin and heparan sulfate (HS), to enhance transformi...