Targeting translation factors in haematologic malignancies.

• Main Author: Lee, Janice Siu Hui.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/44751
• Institution: Nanyang Technological University

Imatinib resistance arose in patients with chronic myeloid leukaemia (CML) due to the alterations in the BCR-ABL kinase domain. It was established that the elevated β-catenin activation led to the progression of CML from chronic phase to blast crisis phase. Inhibition of phosphorylated eIF4E (p-eIF4...