Targeting translation factors in haematologic malignancies.
Imatinib resistance arose in patients with chronic myeloid leukaemia (CML) due to the alterations in the BCR-ABL kinase domain. It was established that the elevated β-catenin activation led to the progression of CML from chronic phase to blast crisis phase. Inhibition of phosphorylated eIF4E (p-eIF4...
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| 格式: | Final Year Project |
| 語言: | English |
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2011
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| 在線閱讀: | http://hdl.handle.net/10356/44751 |
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