A vaccination strategy to prevent experimental cerebral malaria.

Infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) induces a syndrome called experimental cerebral malaria (ECM) in mice, commonly used as a model to study cerebral malaria (CM) in humans, a major complication of Plasmodium falciparum infection. In this study we showed that immunization of...

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Main Author: Ong, Joanne Wei En.
Other Authors: School of Biological Sciences
Format: Final Year Project
Language:English
Published: 2011
Subjects:
Online Access:http://hdl.handle.net/10356/45106
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-451062023-02-28T17:59:53Z A vaccination strategy to prevent experimental cerebral malaria. Ong, Joanne Wei En. School of Biological Sciences A*STAR Singapore Immunology Network Laurent Rénia Marjorie Mauduit DRNTU::Science::Biological sciences::Microbiology::Immunology Infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) induces a syndrome called experimental cerebral malaria (ECM) in mice, commonly used as a model to study cerebral malaria (CM) in humans, a major complication of Plasmodium falciparum infection. In this study we showed that immunization of C57BL/6 mice with live erythrocytes infected with PbA under chloroquine cover confers a partial protection against blood stage infection. This protection is mediated by antibodies. Although immunization was able to induce a reduction of parasitemia in peripheral blood and a decrease of parasite sequestration in the brain at the time of ECM onset, T cells sequestration in the brain remained unchanged and immunization did not prevent the occurrence of ECM. These findings have provided new insights into the possible prevention of CM through appropriate vaccination. Bachelor of Science in Biological Sciences 2011-06-09T02:59:32Z 2011-06-09T02:59:32Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/45106 en Nanyang Technological University 31 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Microbiology::Immunology
spellingShingle DRNTU::Science::Biological sciences::Microbiology::Immunology
Ong, Joanne Wei En.
A vaccination strategy to prevent experimental cerebral malaria.
description Infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) induces a syndrome called experimental cerebral malaria (ECM) in mice, commonly used as a model to study cerebral malaria (CM) in humans, a major complication of Plasmodium falciparum infection. In this study we showed that immunization of C57BL/6 mice with live erythrocytes infected with PbA under chloroquine cover confers a partial protection against blood stage infection. This protection is mediated by antibodies. Although immunization was able to induce a reduction of parasitemia in peripheral blood and a decrease of parasite sequestration in the brain at the time of ECM onset, T cells sequestration in the brain remained unchanged and immunization did not prevent the occurrence of ECM. These findings have provided new insights into the possible prevention of CM through appropriate vaccination.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Ong, Joanne Wei En.
format Final Year Project
author Ong, Joanne Wei En.
author_sort Ong, Joanne Wei En.
title A vaccination strategy to prevent experimental cerebral malaria.
title_short A vaccination strategy to prevent experimental cerebral malaria.
title_full A vaccination strategy to prevent experimental cerebral malaria.
title_fullStr A vaccination strategy to prevent experimental cerebral malaria.
title_full_unstemmed A vaccination strategy to prevent experimental cerebral malaria.
title_sort vaccination strategy to prevent experimental cerebral malaria.
publishDate 2011
url http://hdl.handle.net/10356/45106
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