An oncogenic role for transcription factor ERG in prostate cancer progression: promoting androgen-independent growth and survival.

• Main Author: Sng, Noel Yan Wei.
• Other Authors: Edwin Chong Wing Cheung
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: http://hdl.handle.net/10356/45108
• Institution: Nanyang Technological University

The discovery of recurrent gene fusions between AR-regulated transmembrane protease and ERG has shed new light on the molecular events that may contribute to the development and progression of prostate cancer. Since then, there has been increasing evidence from clinical studies reporting that ERG is...