Simvastatin enhances the efficacy of Bcr-Abl tyrosine kinase inhibitor nilotinib in chronic myeloid leukemia.

• Main Author: Koh, Yanqing.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/45121
• Institution: Nanyang Technological University

One of the major challenges in treatment of chronic myeloid leukemia (CML) is the continual emergence of new resistance to single agent Bcr-Abl tyrosine kinase inhibitors (TKIs). A strategy to cope with cancer progression is by targeting multiple levels of signaling pathways downstream of B...