Generation of induced pluripotent stem cells from a newly identified type of laminopathy - 'proof of principle'.

• Main Author: Chua, Bernice Hong Min.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: http://hdl.handle.net/10356/45136
• Institution: Nanyang Technological University

Laminopathies constitute a family of disease caused by mutations in the lamin proteins which includes lamin A/C and lamin B1/2. Recently, a new type of laminopathy characterised by inherited heart disease and limb abnormalities was identified. Patients with this disease are at risk of sudden cardiac...