Effects of micro and nanotopography on hematopoietic cell fate decision

• Main Author: Lim, Kuan Chien.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Cytology
• Online Access: http://hdl.handle.net/10356/45337
• Institution: Nanyang Technological University

The lack of an appropriate in vitro model is currently one of the major bottlenecks in studying hematopoietic stem cell behaviors. In vivo, hematopoietic cells reside in the bone marrow niche where a wealth of microenvironmental information comprising biochemical and biophysical topographical cues a...