Investigation of combinatory drug mix on cell behavior

• Main Author: Arora, Shuchi
• Other Authors: Lim Chu Sing
• Format: Theses and Dissertations
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology; DRNTU::Engineering::Chemical engineering::Biotechnology
• Online Access: https://hdl.handle.net/10356/45594
• Institution: Nanyang Technological University

Real-time combinatory drug responses on biological cells have become important for drug screenings with growing threat of diseases. Though rapid progress has been made in the field of biotechnology and pharmacy, the need to understand the effects of drug combinations, such as antibiotics and herbal medicines, on cells have become essential. Drug combinations are used to accelerate and/or increase the efficacy of a treatment. In case of infectious diseases, however, the predicaments of drug resistance prevail in the contemporary scenario. Drug combinations, in these cases, are mainly used to overcome such resistance by the disease causing pathogens. The present project created a unique system that can simultaneously investigate cell behavior exposed to a combinatory mixture of drugs. The system was aimed to conduct novel studies of combinatory drug performance on various cell types in vitro. Protocols for handling different cell types that require different culture conditions were established.