Surface modification of rare earth nanoparticles for the attachment of drugs.
Rare earth upconversion nanoparticles (UCNPs) are proving indispensable in various fields of research today ranging from electronic sectors to the biomedical field. In the biomedical field, rare earth UCNPs are explored for their use as fluorescent biomarkers for their use in bioimaging. Traditional...
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sg-ntu-dr.10356-456292023-03-03T15:39:49Z Surface modification of rare earth nanoparticles for the attachment of drugs. Stanislaws, Anna Marina. School of Chemical and Biomedical Engineering Huang Ling DRNTU::Science::Chemistry::Physical chemistry::Surface chemistry DRNTU::Engineering::Chemical engineering::Biotechnology Rare earth upconversion nanoparticles (UCNPs) are proving indispensable in various fields of research today ranging from electronic sectors to the biomedical field. In the biomedical field, rare earth UCNPs are explored for their use as fluorescent biomarkers for their use in bioimaging. Traditional down conversion nanophosphors used as luminescent labels exhibit several problems such as low light penetration depth and possible severe photodamage to living organisms. Hence in this project we explore the synthesis of rare earth UCNPs which have a greater advantage over the traditional form as they cause minimal damage to biological tissues and allow deep penetration of NIR radiation. We explore the synthesis of NaYF4:Yb,Er UCNPs surface functionalized with the carboxyl functional group for the attachment of drug through the thermal decomposition, hydrothermal and solvothermal approaches. Their effectiveness to generate NPs which exhibit good surface functionality and solubility for their use in drug delivery into cells when conjugated with Ara-C is then evaluated through FT-IR and TEM imaging. The most efficient strategy can then be adopted to synthesize UCNPs surface-functionalised with other groups to allow greater use in the biomedical field. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2011-06-15T08:18:38Z 2011-06-15T08:18:38Z 2011 2011 Final Year Project (FYP) http://hdl.handle.net/10356/45629 en Nanyang Technological University 47 p. application/pdf |
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DRNTU::Science::Chemistry::Physical chemistry::Surface chemistry DRNTU::Engineering::Chemical engineering::Biotechnology Stanislaws, Anna Marina. Surface modification of rare earth nanoparticles for the attachment of drugs. |
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Rare earth upconversion nanoparticles (UCNPs) are proving indispensable in various fields of research today ranging from electronic sectors to the biomedical field. In the biomedical field, rare earth UCNPs are explored for their use as fluorescent biomarkers for their use in bioimaging. Traditional down conversion nanophosphors used as luminescent labels exhibit several problems such as low light penetration depth and possible severe photodamage to living organisms. Hence in this project we explore the synthesis of rare earth UCNPs which have a greater advantage over the traditional form as they cause minimal damage to biological tissues and allow deep penetration of NIR radiation. We explore the synthesis of NaYF4:Yb,Er UCNPs surface functionalized with the carboxyl functional group for the attachment of drug through the thermal decomposition, hydrothermal and solvothermal approaches. Their effectiveness to generate NPs which exhibit good surface functionality and solubility for their use in drug delivery into cells when conjugated with Ara-C is then evaluated through FT-IR and TEM imaging. The most efficient strategy can then be adopted to synthesize UCNPs surface-functionalised with other groups to allow greater use in the biomedical field. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Stanislaws, Anna Marina. |
format |
Final Year Project |
author |
Stanislaws, Anna Marina. |
author_sort |
Stanislaws, Anna Marina. |
title |
Surface modification of rare earth nanoparticles for the attachment of drugs. |
title_short |
Surface modification of rare earth nanoparticles for the attachment of drugs. |
title_full |
Surface modification of rare earth nanoparticles for the attachment of drugs. |
title_fullStr |
Surface modification of rare earth nanoparticles for the attachment of drugs. |
title_full_unstemmed |
Surface modification of rare earth nanoparticles for the attachment of drugs. |
title_sort |
surface modification of rare earth nanoparticles for the attachment of drugs. |
publishDate |
2011 |
url |
http://hdl.handle.net/10356/45629 |
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1759857487444443136 |