Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels

The creation of a functioning vascular tunica media, with circumferentially positioned contractile vascular smooth muscle cells (vSMCs) and extracellular matrix, suitable mechanical characteristics and vasoactivity has yet to be established for tissue engineering of small calibre blood vessels. Synt...

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Main Author: Kang, Gavin Chun Wui
Other Authors: Chan Bee Eng, Mary
Format: Theses and Dissertations
Language:English
Published: 2011
Subjects:
Online Access:https://hdl.handle.net/10356/46249
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-462492023-03-03T15:59:31Z Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels Kang, Gavin Chun Wui Chan Bee Eng, Mary School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Tissue engineering The creation of a functioning vascular tunica media, with circumferentially positioned contractile vascular smooth muscle cells (vSMCs) and extracellular matrix, suitable mechanical characteristics and vasoactivity has yet to be established for tissue engineering of small calibre blood vessels. Synthetic vSMC is preferred for cell proliferation needed for vessel remodeling but the contractile vSMC is essential for sufficient vasoactivity and prevention of neoinitima formation. The vessels' tunica media is composed chiefly of vSMCs that when possessing contractile phenotype will endow the vessel with contractility-vasoactivity. The transformation of SMC phenotype from synthetic to contractile at the correct cell development stage has been hypothesized to be crucial for producing a functional vascular tunica media. MASTER OF ENGINEERING (SCBE) 2011-07-08T06:01:24Z 2011-07-08T06:01:24Z 2010 2010 Thesis Kang, G. C. W. (2010). Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels. Master’s thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/46249 10.32657/10356/46249 en 82 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Medicine::Tissue engineering
spellingShingle DRNTU::Science::Medicine::Tissue engineering
Kang, Gavin Chun Wui
Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels
description The creation of a functioning vascular tunica media, with circumferentially positioned contractile vascular smooth muscle cells (vSMCs) and extracellular matrix, suitable mechanical characteristics and vasoactivity has yet to be established for tissue engineering of small calibre blood vessels. Synthetic vSMC is preferred for cell proliferation needed for vessel remodeling but the contractile vSMC is essential for sufficient vasoactivity and prevention of neoinitima formation. The vessels' tunica media is composed chiefly of vSMCs that when possessing contractile phenotype will endow the vessel with contractility-vasoactivity. The transformation of SMC phenotype from synthetic to contractile at the correct cell development stage has been hypothesized to be crucial for producing a functional vascular tunica media.
author2 Chan Bee Eng, Mary
author_facet Chan Bee Eng, Mary
Kang, Gavin Chun Wui
format Theses and Dissertations
author Kang, Gavin Chun Wui
author_sort Kang, Gavin Chun Wui
title Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels
title_short Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels
title_full Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels
title_fullStr Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels
title_full_unstemmed Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels
title_sort effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels
publishDate 2011
url https://hdl.handle.net/10356/46249
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