Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels
The creation of a functioning vascular tunica media, with circumferentially positioned contractile vascular smooth muscle cells (vSMCs) and extracellular matrix, suitable mechanical characteristics and vasoactivity has yet to be established for tissue engineering of small calibre blood vessels. Synt...
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sg-ntu-dr.10356-462492023-03-03T15:59:31Z Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels Kang, Gavin Chun Wui Chan Bee Eng, Mary School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Tissue engineering The creation of a functioning vascular tunica media, with circumferentially positioned contractile vascular smooth muscle cells (vSMCs) and extracellular matrix, suitable mechanical characteristics and vasoactivity has yet to be established for tissue engineering of small calibre blood vessels. Synthetic vSMC is preferred for cell proliferation needed for vessel remodeling but the contractile vSMC is essential for sufficient vasoactivity and prevention of neoinitima formation. The vessels' tunica media is composed chiefly of vSMCs that when possessing contractile phenotype will endow the vessel with contractility-vasoactivity. The transformation of SMC phenotype from synthetic to contractile at the correct cell development stage has been hypothesized to be crucial for producing a functional vascular tunica media. MASTER OF ENGINEERING (SCBE) 2011-07-08T06:01:24Z 2011-07-08T06:01:24Z 2010 2010 Thesis Kang, G. C. W. (2010). Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels. Master’s thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/46249 10.32657/10356/46249 en 82 p. application/pdf |
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DRNTU::Science::Medicine::Tissue engineering Kang, Gavin Chun Wui Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels |
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The creation of a functioning vascular tunica media, with circumferentially positioned contractile vascular smooth muscle cells (vSMCs) and extracellular matrix, suitable mechanical characteristics and vasoactivity has yet to be established for tissue engineering of small calibre blood vessels. Synthetic vSMC is preferred for cell proliferation needed for vessel remodeling but the contractile vSMC is essential for sufficient vasoactivity and prevention of neoinitima formation. The vessels' tunica media is composed chiefly of vSMCs that when possessing contractile phenotype will endow the vessel with contractility-vasoactivity. The transformation of SMC phenotype from synthetic to contractile at the correct cell development stage has been hypothesized to be crucial for producing a functional vascular tunica media. |
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Chan Bee Eng, Mary |
author_facet |
Chan Bee Eng, Mary Kang, Gavin Chun Wui |
format |
Theses and Dissertations |
author |
Kang, Gavin Chun Wui |
author_sort |
Kang, Gavin Chun Wui |
title |
Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels |
title_short |
Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels |
title_full |
Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels |
title_fullStr |
Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels |
title_full_unstemmed |
Effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels |
title_sort |
effect of exogenous transforming growth factor beta one on vascular smooth muscle cells in deep microchannels |
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2011 |
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https://hdl.handle.net/10356/46249 |
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1759854226219991040 |