Linker prediction in fragment-based drug design.

• Main Author: Nyam, Ching Wee.
• Other Authors: Mu Yuguang
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Biophysics
• Online Access: http://hdl.handle.net/10356/46708
• Institution: Nanyang Technological University

Fragment-based drug design is a drug discovery technique where 2 fragments each having some degree of pharmacological activity is covalently tethered together using a linker to reap the energetic benefit of their combined pharmacological action. However, the effects of the linker on the binding ener...