Development of scaffolds for oesophageal tissue engineering
254 p.
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2011
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sg-ntu-dr.10356-472572023-03-11T17:27:45Z Development of scaffolds for oesophageal tissue engineering Leong, Meng Fatt Walter Hunziker Chian Kerm Sin, Sandy School of Mechanical and Aerospace Engineering DRNTU::Engineering::Bioengineering 254 p. Tissue engineering has emerged as a potential solution to replace diseased or defective organs. This project describes the development and characterization of a tissue engineered scaffold that is suitable for the replacement of the oesophagus. Electrospinning is chosen as the fabrication method for the scaffold. Despite the versatility of the electrospinning process in fabricating fibrous scaffold, it suffers from the severe limitation of producing scaffold with microscale pores (<5|J.m) that inhibit cell infiltration. In this project, a technique that uses ice crystals as templates to fabricate cryogenic electrospun scaffolds (CES) with large three-dimensional and interconnected pores using poly(D,L-lactide) (PLA) was developed. The pore sizes were controlled by manipulating the environment's humidity, mandrel temperature and solution flow rate. DOCTOR OF PHILOSOPHY (MAE) 2011-12-27T06:47:31Z 2011-12-27T06:47:31Z 2009 2009 Thesis Leong, M. F. (2009). Development of scaffolds for oesophageal tissue engineering. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/47257 10.32657/10356/47257 Nanyang Technological University application/pdf |
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DRNTU::Engineering::Bioengineering |
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DRNTU::Engineering::Bioengineering Leong, Meng Fatt Development of scaffolds for oesophageal tissue engineering |
| description |
254 p. |
| author2 |
Walter Hunziker |
| author_facet |
Walter Hunziker Leong, Meng Fatt |
| format |
Theses and Dissertations |
| author |
Leong, Meng Fatt |
| author_sort |
Leong, Meng Fatt |
| title |
Development of scaffolds for oesophageal tissue engineering |
| title_short |
Development of scaffolds for oesophageal tissue engineering |
| title_full |
Development of scaffolds for oesophageal tissue engineering |
| title_fullStr |
Development of scaffolds for oesophageal tissue engineering |
| title_full_unstemmed |
Development of scaffolds for oesophageal tissue engineering |
| title_sort |
development of scaffolds for oesophageal tissue engineering |
| publishDate |
2011 |
| url |
https://hdl.handle.net/10356/47257 |
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1761781953640529920 |