Thioacid synthesis and application in peptide and protein chemistry
156 p.
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2011
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sg-ntu-dr.10356-474472023-02-28T18:51:25Z Thioacid synthesis and application in peptide and protein chemistry Zhang, Xiaohong Liu Chuan Fa School of Biological Sciences DRNTU::Science::Biological sciences::Biochemistry 156 p. There is an increasing need for the use of synthetic proteins in biomedical research and drug discovery. Since its introduction in 1963, solid phase peptide synthesis (SPPS) has been widely used for the synthesis of peptides and small proteins. In recent years, convergent strategies for protein synthesis have been developed including Kemp's prior thiol capture ligation, thiazolidine-capture ligation, thioester-mediated native chemical ligation, thioacid capture ligation, followed by Staudiger ligation and decarboxylative condensation. Among them, the thioacid capture ligation is probably the most efficient in terms of reaction rate. The main reason for the low use of this method is the difficulty in obtaining the thioacid building blocks. DOCTOR OF PHILOSOPHY (SBS) 2011-12-27T08:18:07Z 2011-12-27T08:18:07Z 2009 2009 Thesis Zhang, X. (2009). Thioacid synthesis and application in peptide and protein chemistry. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/47447 10.32657/10356/47447 Nanyang Technological University application/pdf |
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DRNTU::Science::Biological sciences::Biochemistry Zhang, Xiaohong Thioacid synthesis and application in peptide and protein chemistry |
| description |
156 p. |
| author2 |
Liu Chuan Fa |
| author_facet |
Liu Chuan Fa Zhang, Xiaohong |
| format |
Theses and Dissertations |
| author |
Zhang, Xiaohong |
| author_sort |
Zhang, Xiaohong |
| title |
Thioacid synthesis and application in peptide and protein chemistry |
| title_short |
Thioacid synthesis and application in peptide and protein chemistry |
| title_full |
Thioacid synthesis and application in peptide and protein chemistry |
| title_fullStr |
Thioacid synthesis and application in peptide and protein chemistry |
| title_full_unstemmed |
Thioacid synthesis and application in peptide and protein chemistry |
| title_sort |
thioacid synthesis and application in peptide and protein chemistry |
| publishDate |
2011 |
| url |
https://hdl.handle.net/10356/47447 |
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1759858390283059200 |