Biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers
144 p.
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2011
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| Online Access: | https://hdl.handle.net/10356/47459 |
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sg-ntu-dr.10356-474592023-03-03T16:04:39Z Biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers Chen, Beiyi Chan Vincent School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering::Polymers and polymer manufacture 144 p. Biomaterial surface engineering plays a pivotal role in the design and development of various biomedical devices and engineered tissue equivalents. The modification of tissue culture substrate with thermo-responsive polymer (TRP) has led to the realization of the enzyme-free harvesting of anchorage-dependent cells through an acute increase in surface hydrophilicity of TRP across its lower critical solution temperature (LCST). To date, the intricate mechanisms of cell deadhesion/adhesion on TRP and other bio-functionalized polymer have not been fully investigated. The understanding of biophysical behavior of cells towards the thermo-physical stimulations and biological recognition on biomaterials will be critical to the design of highly tailored cell regeneration processes. In my thesis, highly integrative biophysical approaches are applied to develop quantitative correlation between the biophysics of cell adhesion/deadhesion, receptor-ligand interactions, cytoskeleton reorganization and biomaterial properties. DOCTOR OF PHILOSOPHY (SCBE) 2011-12-27T08:22:19Z 2011-12-27T08:22:19Z 2009 2009 Thesis Chen, B. (2009). Biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/47459 10.32657/10356/47459 Nanyang Technological University application/pdf |
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Asia |
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Singapore Singapore |
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NTU Library |
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DRNTU::Engineering::Chemical engineering::Polymers and polymer manufacture |
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DRNTU::Engineering::Chemical engineering::Polymers and polymer manufacture Chen, Beiyi Biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers |
| description |
144 p. |
| author2 |
Chan Vincent |
| author_facet |
Chan Vincent Chen, Beiyi |
| format |
Theses and Dissertations |
| author |
Chen, Beiyi |
| author_sort |
Chen, Beiyi |
| title |
Biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers |
| title_short |
Biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers |
| title_full |
Biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers |
| title_fullStr |
Biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers |
| title_full_unstemmed |
Biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers |
| title_sort |
biophysical dynamics of smooth muscle cell on thermo-responsive and bio-functionalized polymers |
| publishDate |
2011 |
| url |
https://hdl.handle.net/10356/47459 |
| _version_ |
1759856478243520512 |