Syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary.

87 p.

Saved in:

Bibliographic Details
Main Author:	Wong, Shwo Mun.
Other Authors:	Loh Teck Peng
Format:	Theses and Dissertations
Published:	2011
Subjects:	DRNTU::Science::Chemistry
Online Access:	http://hdl.handle.net/10356/47506
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	Nanyang Technological University

id	sg-ntu-dr.10356-47506
record_format	dspace
spelling	sg-ntu-dr.10356-475062023-02-28T23:46:35Z Syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary. Wong, Shwo Mun. Loh Teck Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry 87 p. The extensive occurrence of nitrogenated compounds in the nature and the promising outlook of synthesizing enantiomerically pure compounds in asymmetric reactions, the stereoselective additions to C=N bonds are now considered salient and fundamental reactions.The C=N functionalities are possible to determine the final products to be either amines (from imines and iminium salts) or hydroxylamines (from nitrones and oximes), which could later be transformed into useful building blocks like amino alcohols, amino acids and nitrogenated heterocycles such as isoxazolidine. A variety of nitrogen containing functional groups can be prepared by introducing the allyl moiety such as Grignard reagent or stannane reagent. The diastereoselective allylations can be performed in the presence of either a chiral lewis acid or a chiral auxiliary group. The discoveries of chiral Lewis acid systems and its applications are widely demonstrated in many papers; however, a very few examples of diastereoselective allylations are performed via chiral auxiliary group have been reported so far. Therefore, the development of allylation of nitrones using sugar template as a chiral auxiliary is highly desirable. Master of Science 2011-12-27T08:31:10Z 2011-12-27T08:31:10Z 2010 2010 Thesis http://hdl.handle.net/10356/47506 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Science::Chemistry
spellingShingle	DRNTU::Science::Chemistry Wong, Shwo Mun. Syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary.
description	87 p.
author2	Loh Teck Peng
author_facet	Loh Teck Peng Wong, Shwo Mun.
format	Theses and Dissertations
author	Wong, Shwo Mun.
author_sort	Wong, Shwo Mun.
title	Syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary.
title_short	Syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary.
title_full	Syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary.
title_fullStr	Syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary.
title_full_unstemmed	Syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary.
title_sort	syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary.
publishDate	2011
url	http://hdl.handle.net/10356/47506
_version_	1759855719323009024

Syntheses of enantioenriched homoallylic hydroxylamines and ß-lactams using sugar template as the chiral auxiliary.

Similar Items