Towards the design of drugs against the dengue virus RNA dependent RNA polymerase : mechanistic studies of enzyme activities and substrate binding.

• Main Author: Koh, Jolene Hong Kiew.
• Other Authors: Julien Lescar
• Format: Final Year Project
• Language: English
• Published: 2012
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/49269
• Institution: Nanyang Technological University

Dengue NS5 consists of 2 domains- methyltransferase and RNA-dependent RNA polymerase (RdRp), interspersed by a 9 amino acid linker. Currently, the full-length (FL) NS5 has not been structurally determined due to the flexibility of this linker, impeding drug discovery efforts. Here, FL NS5 with alani...