Neurobehavioral and biochemical features of a mouse model for Parkinson’s disease.
Parkinson’s disease (PD) is a common age-related neurodegenerative disorder, characterized by degradation of dopaminergic neurons. The cardinal signs of PD are mainly motor dysfunctions. Non-motor symptoms, including anxiety and depression, which often precede motor symptoms, may also manifest. Thes...
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sg-ntu-dr.10356-493862023-02-28T18:05:35Z Neurobehavioral and biochemical features of a mouse model for Parkinson’s disease. Lee, Elianna Shu Hui. School of Biological Sciences National Neuroscience Institute Zoë Bichler DRNTU::Science::Biological sciences::Zoology::Animal behavior DRNTU::Science::Biological sciences::Zoology::Vertebrates DRNTU::Science::Biological sciences::Zoology::Morphology Parkinson’s disease (PD) is a common age-related neurodegenerative disorder, characterized by degradation of dopaminergic neurons. The cardinal signs of PD are mainly motor dysfunctions. Non-motor symptoms, including anxiety and depression, which often precede motor symptoms, may also manifest. These behavioral phenotypes are commonly investigated through mice models. Due to widespread prevalence and early manifestation in patients, the role of non-motor symptoms is increasingly important in understanding the onset of PD. We aimed to characterize the onset of non-motor symptoms, in relation to the motor disorders, within a transgenic mouse model of PD. A longitudinal study of anxiety- and depression-like behaviors in mice was done through elevated plus maze and forced swim test. Results showed decreasing levels of anxiety-like behavior between ages 4 to 14 months while the level of depression-like behavior peaked in 4 and 12 months old mice. However, as concomitant increase in locomotion was observed between 4 to 14 months old mice, studies with other models of anxiety and depression may be necessary. No differences in anxiety- and depression-like behaviors were observed between transgenic and non-transgenic mice. Nevertheless, our findings coincide with reported age-associated trends and provided an insight into the correlation of anxiety and depression with PD. Bachelor of Science in Biological Sciences 2012-05-18T02:54:09Z 2012-05-18T02:54:09Z 2012 2012 Final Year Project (FYP) http://hdl.handle.net/10356/49386 en Nanyang Technological University 32 p. application/pdf |
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DRNTU::Science::Biological sciences::Zoology::Animal behavior DRNTU::Science::Biological sciences::Zoology::Vertebrates DRNTU::Science::Biological sciences::Zoology::Morphology Lee, Elianna Shu Hui. Neurobehavioral and biochemical features of a mouse model for Parkinson’s disease. |
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Parkinson’s disease (PD) is a common age-related neurodegenerative disorder, characterized by degradation of dopaminergic neurons. The cardinal signs of PD are mainly motor dysfunctions. Non-motor symptoms, including anxiety and depression, which often precede motor symptoms, may also manifest. These behavioral phenotypes are commonly investigated through mice models. Due to widespread prevalence and early manifestation in patients, the role of non-motor symptoms is increasingly important in understanding the onset of PD. We aimed to characterize the onset of non-motor symptoms, in relation to the motor disorders, within a transgenic mouse model of PD. A longitudinal study of anxiety- and depression-like behaviors in mice was done through elevated plus maze and forced swim test. Results showed decreasing levels of anxiety-like behavior between ages 4 to 14 months while the level of depression-like behavior peaked in 4 and 12 months old mice. However, as concomitant increase in locomotion was observed between 4 to 14 months old mice, studies with other models of anxiety and depression may be necessary. No differences in anxiety- and depression-like behaviors were observed between transgenic and non-transgenic mice. Nevertheless, our findings coincide with reported age-associated trends and provided an insight into the correlation of anxiety and depression with PD. |
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School of Biological Sciences |
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School of Biological Sciences Lee, Elianna Shu Hui. |
format |
Final Year Project |
author |
Lee, Elianna Shu Hui. |
author_sort |
Lee, Elianna Shu Hui. |
title |
Neurobehavioral and biochemical features of a mouse model for Parkinson’s disease. |
title_short |
Neurobehavioral and biochemical features of a mouse model for Parkinson’s disease. |
title_full |
Neurobehavioral and biochemical features of a mouse model for Parkinson’s disease. |
title_fullStr |
Neurobehavioral and biochemical features of a mouse model for Parkinson’s disease. |
title_full_unstemmed |
Neurobehavioral and biochemical features of a mouse model for Parkinson’s disease. |
title_sort |
neurobehavioral and biochemical features of a mouse model for parkinson’s disease. |
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2012 |
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http://hdl.handle.net/10356/49386 |
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1759854172595814400 |