Role of distinct dendritic cell subsets in disseminated candidiasis.

Candida albicans is a human commensal and an opportunistic pathogen causing disseminated candidiasis in the immunocompromised. The incidence of such cases has been growing and this is also associated with a rising incidence of antifungal resistance. This makes it imperative to find other avenues for...

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Main Author: Teoh, Flora Poh Leng.
Other Authors: Ruedl Christiane
Format: Final Year Project
Language:English
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/10356/49388
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-493882023-02-28T18:01:32Z Role of distinct dendritic cell subsets in disseminated candidiasis. Teoh, Flora Poh Leng. Ruedl Christiane School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology::Immunology Candida albicans is a human commensal and an opportunistic pathogen causing disseminated candidiasis in the immunocompromised. The incidence of such cases has been growing and this is also associated with a rising incidence of antifungal resistance. This makes it imperative to find other avenues for treating and preventing the disease. By finding immune cells that play a role in host defense against C. albicans, we may discover potential targets for vaccination and other immunotherapies. In this study, acute disseminated candidiasis was examined in the mouse model. Using diphtheria toxin-mediated cell ablation, we found that the ablation of conventional dendritic cells and marginal metallophilic macrophages result in reduced infiltration of neutrophils in the spleen. This suggests that these cells play a role in the neutrophil response, which is known to be critical in controlling disseminated candidiasis. Bachelor of Science in Biological Sciences 2012-05-18T03:01:38Z 2012-05-18T03:01:38Z 2012 2012 Final Year Project (FYP) http://hdl.handle.net/10356/49388 en Nanyang Technological University 31 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Microbiology::Immunology
spellingShingle DRNTU::Science::Biological sciences::Microbiology::Immunology
Teoh, Flora Poh Leng.
Role of distinct dendritic cell subsets in disseminated candidiasis.
description Candida albicans is a human commensal and an opportunistic pathogen causing disseminated candidiasis in the immunocompromised. The incidence of such cases has been growing and this is also associated with a rising incidence of antifungal resistance. This makes it imperative to find other avenues for treating and preventing the disease. By finding immune cells that play a role in host defense against C. albicans, we may discover potential targets for vaccination and other immunotherapies. In this study, acute disseminated candidiasis was examined in the mouse model. Using diphtheria toxin-mediated cell ablation, we found that the ablation of conventional dendritic cells and marginal metallophilic macrophages result in reduced infiltration of neutrophils in the spleen. This suggests that these cells play a role in the neutrophil response, which is known to be critical in controlling disseminated candidiasis.
author2 Ruedl Christiane
author_facet Ruedl Christiane
Teoh, Flora Poh Leng.
format Final Year Project
author Teoh, Flora Poh Leng.
author_sort Teoh, Flora Poh Leng.
title Role of distinct dendritic cell subsets in disseminated candidiasis.
title_short Role of distinct dendritic cell subsets in disseminated candidiasis.
title_full Role of distinct dendritic cell subsets in disseminated candidiasis.
title_fullStr Role of distinct dendritic cell subsets in disseminated candidiasis.
title_full_unstemmed Role of distinct dendritic cell subsets in disseminated candidiasis.
title_sort role of distinct dendritic cell subsets in disseminated candidiasis.
publishDate 2012
url http://hdl.handle.net/10356/49388
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