Material characterization of ca-alginate hydrogel
Biopolymeric hydrogels have been utilized as a technique to provide three-dimensional structures and microenvironment for many cell types in-vitro and in-vivo. Ca-alginate hydrogels have the potential of being a biocompatible polymeric scaffold with structurally similarity to the extra-cellular matr...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project |
| Language: | English |
| Published: |
2012
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/49825 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Biopolymeric hydrogels have been utilized as a technique to provide three-dimensional structures and microenvironment for many cell types in-vitro and in-vivo. Ca-alginate hydrogels have the potential of being a biocompatible polymeric scaffold with structurally similarity to the extra-cellular matrix. Recently in our lab, we have shown that it is able to support proliferation of encapsulated hematopoietic stem cells in-vitro. To better understand and control the impact of biophysical cues provided by alginate hydrogels, we performed mechanical and structural characterization of Ca-alginate hydrogels in varying chemical compositions. In this study, the effects of alginate viscosity, calcium ions and alginate concentration on the mechanical properties, surface topography, and swelling abilities were investigated. |
|---|