Drug release mechanisms from bioerodible polymers for stent application

The effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, cryst...

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Main Author:	Alexis, Frank
Other Authors:	Subbu S. Venkatraman
Format:	Theses and Dissertations
Published:	2008
Subjects:	DRNTU::Engineering::Materials::Biomaterials
Online Access:	https://hdl.handle.net/10356/5048
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Institution:	Nanyang Technological University

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spelling	sg-ntu-dr.10356-50482023-03-04T16:46:56Z Drug release mechanisms from bioerodible polymers for stent application Alexis, Frank Subbu S. Venkatraman School of Materials Science & Engineering Freddy Boey DRNTU::Engineering::Materials::Biomaterials The effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, crystallinity and molecular weight. We showed in this study that the drug in the base form has a substantial effect on the release characteristics, through an accelerating effect on matrix degradation. Study of drug release from PdlLGA showed that lidocaine salt followed a triphasic release pattern, in contrast to the biphasic release of the lidocaine. DOCTOR OF PHILOSOPHY (SME) 2008-09-17T10:18:24Z 2008-09-17T10:18:24Z 2005 2005 Thesis Alexis, F. (2005). Drug release mechanisms from bioerodible polymers for stent application. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/5048 10.32657/10356/5048 Nanyang Technological University 245 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Engineering::Materials::Biomaterials
spellingShingle	DRNTU::Engineering::Materials::Biomaterials Alexis, Frank Drug release mechanisms from bioerodible polymers for stent application
description	The effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, crystallinity and molecular weight. We showed in this study that the drug in the base form has a substantial effect on the release characteristics, through an accelerating effect on matrix degradation. Study of drug release from PdlLGA showed that lidocaine salt followed a triphasic release pattern, in contrast to the biphasic release of the lidocaine.
author2	Subbu S. Venkatraman
author_facet	Subbu S. Venkatraman Alexis, Frank
format	Theses and Dissertations
author	Alexis, Frank
author_sort	Alexis, Frank
title	Drug release mechanisms from bioerodible polymers for stent application
title_short	Drug release mechanisms from bioerodible polymers for stent application
title_full	Drug release mechanisms from bioerodible polymers for stent application
title_fullStr	Drug release mechanisms from bioerodible polymers for stent application
title_full_unstemmed	Drug release mechanisms from bioerodible polymers for stent application
title_sort	drug release mechanisms from bioerodible polymers for stent application
publishDate	2008
url	https://hdl.handle.net/10356/5048
_version_	1759857578707255296

Drug release mechanisms from bioerodible polymers for stent application

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