Engineered antibiotic nanoparticles for inhaled anti-biofilm therapy

• Main Author: Cheow, Wean Sin
• Other Authors: Kunn Hadinoto Ong
• Format: Theses and Dissertations
• Language: English
• Published: 2012
• Subjects: DRNTU::Engineering::Nanotechnology; DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology
• Online Access: https://hdl.handle.net/10356/50754
• Institution: Nanyang Technological University

Biofilm, a sessile community of bacterial cells that is enclosed by a self-secreted matrix composed of an extracellular polymeric substance, is implicated in the chronic pulmonary infection of patients with impaired lung mucociliary clearance mechanism, such as cystic fibrosis and chronic obstructiv...