Modeling and simulation of nucleosomes

• Main Author: Yang, Ye
• Other Authors: Lars Nordenskiold
• Format: Theses and Dissertations
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences::Biophysics; DRNTU::Engineering::Computer science and engineering::Computer applications::Physical sciences and engineering; DRNTU::Science::Chemistry::Physical chemistry
• Online Access: https://hdl.handle.net/10356/50806
• Institution: Nanyang Technological University

Nucleosome is composed of highly charged DNA and histones with unstructured termini exposed to the outside. In nucleus, huge number of them are aggregated and highly compacted. In order to elucidate the roles of tails and cations of various valances in NCP aggregation and single nucleosome array fol...