In silico folding and aggregation study of human amylin, an amyloidosis protein

In silico folding and aggregation study of human amylin, an amyloidosis protein

Abnormal self-assembly of proteins converting their native conformations into β-sheet rich fibrillar structures is the hallmark of several so called "misfolding diseases" including Type 2 Diabetes Mellitus (T2DM), Alzheimer's and Parkinson's diseases, etc. Human islet amyloid pol...

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Main Author: Jiang, Ping
Other Authors: Mu Yuguang
Format: Theses and Dissertations
Language:English
Published: 2012
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/50957
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-509572023-02-28T18:34:19Z In silico folding and aggregation study of human amylin, an amyloidosis protein Jiang, Ping Mu Yuguang School of Biological Sciences DRNTU::Science::Biological sciences Abnormal self-assembly of proteins converting their native conformations into β-sheet rich fibrillar structures is the hallmark of several so called "misfolding diseases" including Type 2 Diabetes Mellitus (T2DM), Alzheimer's and Parkinson's diseases, etc. Human islet amyloid polypeptide (hlAPP or amylin) is the major component of amyloid deposits found in the pancreas of 90% T2DM patients. Although extensive studies have been performed in the recent decades, detailed information about hIAPP aggregation and the related pathology remains missing. DOCTOR OF PHILOSOPHY (SBS) 2012-12-26T06:44:26Z 2012-12-26T06:44:26Z 2011 2011 Thesis Jiang, P. (2011). In silico folding and aggregation study of human amylin, an amyloidosis protein. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/50957 10.32657/10356/50957 en 142 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences
spellingShingle DRNTU::Science::Biological sciences
Jiang, Ping
In silico folding and aggregation study of human amylin, an amyloidosis protein
description Abnormal self-assembly of proteins converting their native conformations into β-sheet rich fibrillar structures is the hallmark of several so called "misfolding diseases" including Type 2 Diabetes Mellitus (T2DM), Alzheimer's and Parkinson's diseases, etc. Human islet amyloid polypeptide (hlAPP or amylin) is the major component of amyloid deposits found in the pancreas of 90% T2DM patients. Although extensive studies have been performed in the recent decades, detailed information about hIAPP aggregation and the related pathology remains missing.
author2 Mu Yuguang
author_facet Mu Yuguang
Jiang, Ping
format Theses and Dissertations
author Jiang, Ping
author_sort Jiang, Ping
title In silico folding and aggregation study of human amylin, an amyloidosis protein
title_short In silico folding and aggregation study of human amylin, an amyloidosis protein
title_full In silico folding and aggregation study of human amylin, an amyloidosis protein
title_fullStr In silico folding and aggregation study of human amylin, an amyloidosis protein
title_full_unstemmed In silico folding and aggregation study of human amylin, an amyloidosis protein
title_sort in silico folding and aggregation study of human amylin, an amyloidosis protein
publishDate 2012
url https://hdl.handle.net/10356/50957
_version_ 1759853883198275584

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