Investigation into dual modality fiber probe imaging system

• Main Author: Manu Vaishakh
• Other Authors: Murukeshan Vadakke Matham
• Format: Theses and Dissertations
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Mechanical engineering
• Online Access: https://hdl.handle.net/10356/51008
• Institution: Nanyang Technological University

Optical techniques like microscopy and spectroscopy have become an indispensable tool in the clinical environment. Interfacing optical fibers into the interrogation system provides a flexible solution for studying regions inside tubular structures and cavities which are inaccessible by conventional techniques. This has resulted in employing optical fiber probes for studying biochemical changes and for medical diagnostics. They can be used both for imaging as well as for spectroscopic studies. Cancerous changes occurring in tissues result in a difference in morphology or abnormal growths. Sometimes, the morphological changes occur at a later stage and abnormal growths can fall into the false positive category. Apart from the visual changes, cancerous progression can also result in a difference in fluorescence wavelength, fluorescence intensity or fluorescence lifetime. Integrating spectroscopic and imaging modalities into one system can improve the sensitivity and accuracy in diagnosis.