Effect of AngiotensiN1-7/MAS receptor interaction on adipogenesis.

• Main Author: Xu, Tong.
• Other Authors: Chen Peng
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering
• Online Access: http://hdl.handle.net/10356/51098
• Institution: Nanyang Technological University

Adipose tissue is not only a main depot to store excess energy but also an endocrine organ which is involved in regulating energy and glucose homeostasis. Currently, rennin-angiotensin system (RAS), proved to be fully expressed in adipocytes, has become a research focus due to the regulatory effect on adipocytes. RAS has two counter-functional arms, the Angiotensin II (AngII) arm and Angiotensin 1-7 (Ang1-7) arm. Ang II, mainly angiotensin receptor type 1 and 2 (AT1 and AT2 receptore) mediated, is shown to play a critical in regulating crucial adipocyte behaviors which has an anti-adipogentic and lipogentic effects. Besides, it’s become evident that increased plasma Ang II concentration is associated with obesity and increased insulin resistance. Subsequently, Ang 1-7, a new member of RAS family, is considered as a therapeutic agent due to its counter-regulatory effect to Ang II. In fact, a larger body of evidence has shown Ang 1-7/Mas axis is involved in glucose and lipid metabolism suggesting the ability of overcoming insulin resistance and decreasing body fat against high-fat diet by regulating adipocytes via Mas receptor signaling pathway. Anyway, relation between Ang 1-7 and adipocytes is still elusive comparing to the well-established Ang II mechanism. In present study, we demonstrated that Ang 1-7 not only promotes adipogenesis in adipocytes but also reverses the AT1 mediated anti-adipogentic effect of Ang II. Ang 1-7 is able to induce adipogenesis in both undifferentiated adipocytes as well as mature adipocytes. We also shown the adipogenic effect of Ang 1-7 is correlated to the transcriptional factor PPARγ.