Study of the effects of nanostructuring of polymer surfaces on cellular proliferation and alignment
Synthetic bioabsorbable polymers have been increasingly investigated as an alternative material for cardiovascular applications, attributed to their bioabsorbable and mechanical properties. However endothelialization on these bioabsorbable polymers appears difficult due to their poor cell a...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/51131 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Synthetic bioabsorbable polymers have been increasingly investigated as an alternative
material for cardiovascular applications, attributed to their bioabsorbable and
mechanical properties. However endothelialization on these bioabsorbable polymers
appears difficult due to their poor cell affinity and their surface roughness. This
research project seeks to study how two different surface modification techniques,
namely electron beam irradiation (ebeam) with sodium hydroxide (NaOH) treatment
and electron beam writing (EBW), have an effect on endothelial cell-surface
interaction and subsequent cell growth. The substrate material candidates chosen in
this study are poly(lactic-co-glycolic acid) (PLGA) co-polymer and poly(L-lactic acid)
(PLLA) polymer, because of their prevalent use as blood contacting devices in
cardiovascular applications.
In this work, randomized pattern obtained using electron beam irradiation with sodium
hydroxide treatment (NaOH), was compared against a nano-dimensional groove
pattern created by electron beam writing (EBW) for their influences on endothelial cell
proliferation and alignment on its films. |
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