Studies of DNA-interacting properties of certain topological enzymes

• المؤلف الرئيسي: Lee, Jasmine Yiqin
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Chemistry
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/51880
• المؤسسة: Nanyang Technological University

Topoisomerases are topological enzymes that are involved in the regulation of DNA supercoiling. In this thesis, two of the type IIA topoisomerases, Topoisomerase II and DNA Gyrase, will be discussed and their DNA-interacting properties will be studied. Firstly, the change in topology of Kine...