Characterization of hippocampal dentate gyrus place cells.
The hippocampus plays an essential role in learning and memory. The discovery of place cells in the hippocampus by O’Keefe in 1971 demonstrated that the hippocampus plays a crucial role in spatial navigation. These place cells are found in the three major sub-regions of the hippocampus: Den...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project |
| Language: | English |
| Published: |
2013
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/52331 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | The hippocampus plays an essential role in learning and memory. The discovery of place cells
in the hippocampus by O’Keefe in 1971 demonstrated that the hippocampus plays a crucial
role in spatial navigation. These place cells are found in the three major sub-regions of the
hippocampus: Dentate gyrus (DG), Cornu Ammonis 1 and 3 (CA1 &CA3). Place cells tend
to fire at a specific location in an environment. Thus, this shows that these neurons encode a
spatial representation of the environment. Hence, the hippocampus has been assumed to play
a role in the formation of a cognitive map which aids in navigation and in memory. A rat was
first pre-trained and then made to explore a circular open arena for 10 minutes, for four
sessions, with an inter-session interval of 5 minutes. Results showed that some of the recorded
neurons in the DG region have an ascribed place cell activity and these neurons fire stably, at
the same location, across all four sessions. These results thus re-established the characteristics
of the DG place cells that were previously found. |
|---|