Characterization of hippocampal CA1 place cells.

Hippocampal place cells play a role in learning and memory, and spatial navigation. Previous studies have shown the presence of place cells in the hippocampus and their characteristics. As part of a project of a PhD student, Mr. Mehdi Fallahnezhad, this research was conducted on rats’ hippocampus CA...

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Main Author: Lua, MinFeng.
Other Authors: School of Biological Sciences
Format: Final Year Project
Language:English
Published: 2013
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Online Access:http://hdl.handle.net/10356/52332
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-523322023-02-28T18:01:27Z Characterization of hippocampal CA1 place cells. Lua, MinFeng. School of Biological Sciences Ayumu Tashiro DRNTU::Science Hippocampal place cells play a role in learning and memory, and spatial navigation. Previous studies have shown the presence of place cells in the hippocampus and their characteristics. As part of a project of a PhD student, Mr. Mehdi Fallahnezhad, this research was conducted on rats’ hippocampus CA1 pyramidal cell layer and required the rats to carry out spatial explorations of both familiar and novel environments. A familiar environment was the arena the rat was first introduced to explore prior to surgery. Each exploration session was for ten minutes. Activity of neuronal cells was recorded using a microdrive, mounted with four tetrodes. Nine principal cells were visually identified, showing place cell-like characteristics, such as remapping when introduced into a novel environment, and stability of spatial-specific firing in a familiar environment after remapping has occurred due to exposure to a novel environment. This suggests the importance of the hippocampal place cells in the process of learning and converting the information to long-term memory. The result of this study could provide a basis or serve as a control for further studies. Bachelor of Science in Biological Sciences 2013-05-06T03:19:52Z 2013-05-06T03:19:52Z 2013 2013 Final Year Project (FYP) http://hdl.handle.net/10356/52332 en Nanyang Technological University 31 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science
spellingShingle DRNTU::Science
Lua, MinFeng.
Characterization of hippocampal CA1 place cells.
description Hippocampal place cells play a role in learning and memory, and spatial navigation. Previous studies have shown the presence of place cells in the hippocampus and their characteristics. As part of a project of a PhD student, Mr. Mehdi Fallahnezhad, this research was conducted on rats’ hippocampus CA1 pyramidal cell layer and required the rats to carry out spatial explorations of both familiar and novel environments. A familiar environment was the arena the rat was first introduced to explore prior to surgery. Each exploration session was for ten minutes. Activity of neuronal cells was recorded using a microdrive, mounted with four tetrodes. Nine principal cells were visually identified, showing place cell-like characteristics, such as remapping when introduced into a novel environment, and stability of spatial-specific firing in a familiar environment after remapping has occurred due to exposure to a novel environment. This suggests the importance of the hippocampal place cells in the process of learning and converting the information to long-term memory. The result of this study could provide a basis or serve as a control for further studies.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Lua, MinFeng.
format Final Year Project
author Lua, MinFeng.
author_sort Lua, MinFeng.
title Characterization of hippocampal CA1 place cells.
title_short Characterization of hippocampal CA1 place cells.
title_full Characterization of hippocampal CA1 place cells.
title_fullStr Characterization of hippocampal CA1 place cells.
title_full_unstemmed Characterization of hippocampal CA1 place cells.
title_sort characterization of hippocampal ca1 place cells.
publishDate 2013
url http://hdl.handle.net/10356/52332
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