Molecular and immunohistochemical analysis with clinical pathological correlation for lung mucinous carcinoma

Invasive lung mucinous adenocarcinoma (IMC) is a rare disease with unique pathological features and uncommon biological manifestations. These tumors may show the same heterogeneous combination of acinar, papillary, lepidic pattern as seen in non-mucinous tumors. The distinction between IMC and metas...

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Main Author: Jiang, Yulin
Other Authors: School of Biological Sciences
Format: Final Year Project
Language:English
Published: 2013
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Online Access:http://hdl.handle.net/10356/52510
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-525102023-02-28T18:00:26Z Molecular and immunohistochemical analysis with clinical pathological correlation for lung mucinous carcinoma Jiang, Yulin School of Biological Sciences Tony Lim Kiat Hon DRNTU::Science Invasive lung mucinous adenocarcinoma (IMC) is a rare disease with unique pathological features and uncommon biological manifestations. These tumors may show the same heterogeneous combination of acinar, papillary, lepidic pattern as seen in non-mucinous tumors. The distinction between IMC and metastatic mucinous carcinoma of other sites is difficult by routine histology. In this study, molecular and immunohistochemical analysis with clinical correlation of 15 IMC cases will be studied. The results showed that IMC was associated with male smokers and showed a phenotype of CK7+, TTF-1+, CK20+, Napsin A+, CDX2- and CK5/6-. TTF-1 positivity suggests that in the context of differentiating IMC from other mucinous tumors metastatic to the lung, evaluation of TTF-1 may have limited diagnostic utility. The molecular profile for IMC showed EGFR- (80%) and KRAS+ (33.3%) which is inconsistent with previous studies suggesting a larger sample size is needed. Hence, more research (e.g. FISH) is required to provide a better diagnosis for IMC. Bachelor of Science in Biological Sciences 2013-05-15T03:13:22Z 2013-05-15T03:13:22Z 2013 2013 Final Year Project (FYP) http://hdl.handle.net/10356/52510 en Nanyang Technological University 30 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science
spellingShingle DRNTU::Science
Jiang, Yulin
Molecular and immunohistochemical analysis with clinical pathological correlation for lung mucinous carcinoma
description Invasive lung mucinous adenocarcinoma (IMC) is a rare disease with unique pathological features and uncommon biological manifestations. These tumors may show the same heterogeneous combination of acinar, papillary, lepidic pattern as seen in non-mucinous tumors. The distinction between IMC and metastatic mucinous carcinoma of other sites is difficult by routine histology. In this study, molecular and immunohistochemical analysis with clinical correlation of 15 IMC cases will be studied. The results showed that IMC was associated with male smokers and showed a phenotype of CK7+, TTF-1+, CK20+, Napsin A+, CDX2- and CK5/6-. TTF-1 positivity suggests that in the context of differentiating IMC from other mucinous tumors metastatic to the lung, evaluation of TTF-1 may have limited diagnostic utility. The molecular profile for IMC showed EGFR- (80%) and KRAS+ (33.3%) which is inconsistent with previous studies suggesting a larger sample size is needed. Hence, more research (e.g. FISH) is required to provide a better diagnosis for IMC.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Jiang, Yulin
format Final Year Project
author Jiang, Yulin
author_sort Jiang, Yulin
title Molecular and immunohistochemical analysis with clinical pathological correlation for lung mucinous carcinoma
title_short Molecular and immunohistochemical analysis with clinical pathological correlation for lung mucinous carcinoma
title_full Molecular and immunohistochemical analysis with clinical pathological correlation for lung mucinous carcinoma
title_fullStr Molecular and immunohistochemical analysis with clinical pathological correlation for lung mucinous carcinoma
title_full_unstemmed Molecular and immunohistochemical analysis with clinical pathological correlation for lung mucinous carcinoma
title_sort molecular and immunohistochemical analysis with clinical pathological correlation for lung mucinous carcinoma
publishDate 2013
url http://hdl.handle.net/10356/52510
_version_ 1759854908633251840