An improved method of quantifying encapsulation efficiency.

• Main Author: Lim, Kelly Sim Yi.
• Other Authors: Chan Chi Chiu
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: http://hdl.handle.net/10356/52885
• Institution: Nanyang Technological University

Liposomes applications include their roles in nanotechnology drug delivery system, biosensor, immunoassay and many more. Liposomes can also be used to deliver gold nanoparticles which are able to produce plasmonic photothermal effect used for cancer therapy. Although their optical properties have often been used for characterisation, their potential as optical devices has been neglected. To utilise liposomes in the bio-optics field, it is important to know the exact amount of encapsulants they contain to further modify their functionality. Thus, it is of upmost important to quantify the encapsulation efficiency of liposome to ensure its efficacy. Encapsulation efficiency allows one to account for the amount of encapsulants encapsulated. Many literatures had performed research on this area however, most of them were not very comprehensive. A main difference between this project and the others lie in the technique used to quantify the theoretical encapsulant content. This project focuses on deriving an objective and complete characterisation technique to accurately quantify encapsulation efficiency.