Incidence of microsatellite instability in endometrial cancer patients in the Singaporean population.

• Main Author: Lau, Sein Yan.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/52917
• Institution: Nanyang Technological University

Introduction: HNPCC is a familial tumour which is autosomal dominantly inherited. It is caused by mutations in DNA mismatch repair genes and this increases the probability of endometrial cancer associated with HNPCC. MSI occurs when DNA mismatch repair proteins are defective and this causes alterati...