Microfluidic chip development for medical application

• Main Author: Chong, Zhi Wei.
• Other Authors: Li King Ho Holden
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Manufacturing::Product design; DRNTU::Engineering::Mechanical engineering::Fluid mechanics
• Online Access: http://hdl.handle.net/10356/53442
• Institution: Nanyang Technological University

From inkjet printhead to micro-pneumatic systems, the field of microfluidics has been nothing short of a revolution. With advancements in the technology, micro-fluidics has also opened up a vast array of possibilities in biological applications. By utilizing the micro differences in the cell sizes and deformability of circulating tumor cells (CTCs) and normal blood cells, the complete operation from tumor cell capture to cell counting can now be done on a chip. This Final Year Project focuses on the fluid flow simulation of the Microsieve Lab-Chip Device in order to provide more insights into the design of the micro device prior to manufacturing and laboratory testing via the use of ANSYS Workbench. The study on the flow aims to establish a relation between the entry flow rates of the fluid into the micro device and the formation of dead volumes within the fluid chamber, which may interfere with tumor cell collection. Various designs of the chamber will also be looked into to determine the effect that geometrical design differences may have on the formations of dead volumes within the chamber.