Development of algorithm for constructing and assembling scaffolds for tissue engineering

• Main Author: Wang, Yanqing.
• Other Authors: Leong, Kah Fai
• Format: Theses and Dissertations
• Published: 2008
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: http://hdl.handle.net/10356/5362
• Institution: Nanyang Technological University

This project focused on creating the design and modeling of suitable scaffolds for tissue engineering using Rapid Prototyping (RP) technologies. It encompasses the development of an algorithm in conjunction with computer-aided design (CAD) technologies to construct, layer and assemble three-dimensional scaffolds with controllable macro- and micro-architecture on a computer. This algorithm is employed to slice large scaffolds into layers and create orientation features on layered scaffold for reassembling. It ensures large scaffolds will have uniform cell distribution and are conducive for cell migration and nutrient infiltration which both are important requirements in TE applications. RP fabrication techniques are then employed to build scaffolds according to the CAD models. The application of CAD and RP promises high scaffold qualities with spatially and anatomically accurate three-dimensional forms and desirable macro- and micro-architectures that provide new cost-effective, flexible, and rapid solutions for TE scaffold production.