Surveillance of genetic drift in Influenza A virus with base-specific cleavage and MALDI-TOF mass spectrometry

• Main Author: Gao, Xiang
• Other Authors: Kai Tang
• Format: Theses and Dissertations
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/53730
• Institution: Nanyang Technological University

With the discovery of several matrices which enable the ionization of DNA and RNA, MALDI mass spectrometry has become a powerful platform for the study of nucleic acid sequence changes, (e.g. mutations, single nucleotide polymorphisms (SNPs), insertion/deletion, alternative splicing, etc.), amount c...