Impact of alginate encapsulation on myeloid leukemia cells.
Leukemia is a type of blood cancer characterized by a neoplastic proliferative expansion of hematopoietic stem cells, which grow in the bone marrow. Current leukemia studies using 2D culture flasks and in vivo animal models have not explained clearly yet how the interactions of cellular component...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/10356/54305 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Leukemia is a type of blood cancer characterized by a neoplastic proliferative expansion of hematopoietic stem cells, which grow in the bone marrow. Current
leukemia studies using 2D culture flasks and in vivo animal models have not explained clearly yet how the interactions of cellular components in the bone marrow and their niches promote the growth of leukemic stem cells and thwart the chemotherapy. To overcome these challenges, the development of an ex vivo bone marrow model is extensively employed for leukemia study. |
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