Early diagosis of malaria using surface-enhanced Raman spectroscopy.

Malaria still remains one of most deadly diseases in the world of today and we summarize and cross compare different methodologies used in the current technology for early diagnosis of malaria parasites. Hemozoin is a biocrystal which produced by malaria parasites during digesting the hemoglobin wit...

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Main Author: Xu, Tianyi.
Other Authors: Liu Quan
Format: Theses and Dissertations
Language:English
Published: 2013
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Online Access:http://hdl.handle.net/10356/54351
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-543512023-03-03T16:03:02Z Early diagosis of malaria using surface-enhanced Raman spectroscopy. Xu, Tianyi. Liu Quan School of Chemical and Biomedical Engineering DRNTU::Engineering::Bioengineering Malaria still remains one of most deadly diseases in the world of today and we summarize and cross compare different methodologies used in the current technology for early diagnosis of malaria parasites. Hemozoin is a biocrystal which produced by malaria parasites during digesting the hemoglobin within host cells. It has unique optic properties which has been studies in recent years using various optic technologies for detection of malaria. Surface-enhanced Raman spectroscopy (SERS) has been widely used to enhance the optic signal for measuring the properties of molecules due to its powerful magnification of signal strength. To achieve the goal of detecting malaria in the low concentration, we utilize SERS in this project and several approaches were taken to achieve the best signal enhancement. Subsequently, with detection of Raman shift with different parasite concentrations, we also establish a mathematical correlation between the two. ​Master of Science (Biomedical Engineering) 2013-06-19T06:06:42Z 2013-06-19T06:06:42Z 2013 2013 Thesis http://hdl.handle.net/10356/54351 en 50 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Bioengineering
spellingShingle DRNTU::Engineering::Bioengineering
Xu, Tianyi.
Early diagosis of malaria using surface-enhanced Raman spectroscopy.
description Malaria still remains one of most deadly diseases in the world of today and we summarize and cross compare different methodologies used in the current technology for early diagnosis of malaria parasites. Hemozoin is a biocrystal which produced by malaria parasites during digesting the hemoglobin within host cells. It has unique optic properties which has been studies in recent years using various optic technologies for detection of malaria. Surface-enhanced Raman spectroscopy (SERS) has been widely used to enhance the optic signal for measuring the properties of molecules due to its powerful magnification of signal strength. To achieve the goal of detecting malaria in the low concentration, we utilize SERS in this project and several approaches were taken to achieve the best signal enhancement. Subsequently, with detection of Raman shift with different parasite concentrations, we also establish a mathematical correlation between the two.
author2 Liu Quan
author_facet Liu Quan
Xu, Tianyi.
format Theses and Dissertations
author Xu, Tianyi.
author_sort Xu, Tianyi.
title Early diagosis of malaria using surface-enhanced Raman spectroscopy.
title_short Early diagosis of malaria using surface-enhanced Raman spectroscopy.
title_full Early diagosis of malaria using surface-enhanced Raman spectroscopy.
title_fullStr Early diagosis of malaria using surface-enhanced Raman spectroscopy.
title_full_unstemmed Early diagosis of malaria using surface-enhanced Raman spectroscopy.
title_sort early diagosis of malaria using surface-enhanced raman spectroscopy.
publishDate 2013
url http://hdl.handle.net/10356/54351
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