Mapping of Toca-1 binding site in N-WASP.

• Main Author: Liong, Kai Ni.
• Other Authors: Thirumaran s/o Thanabalu
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/54803
• Institution: Nanyang Technological University

Cancer metastasis contributes greatly to the mortality of cancer patients. It is strongly associated with the formation of actin-rich matrix degrading surface protrusions, called invadopodia, by metastatic carcinoma cells. They resemble podosome produced by immune cells and mediate locomotion throug...