Part I: Functionalizations of silicon-based compounds. Part II: Displacement of halogen atom in aqueous media
This thesis comprised four chapters in two parts: 1) functionalization of silicon-based compounds; 2) displacement of halogen atoms from simple alkyl halides in aquous media. I Overview of functionalizations of silicon-based compounds Chapter 1 reviewed the recent development of functionlization of...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2014
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| Online Access: | https://hdl.handle.net/10356/55405 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | This thesis comprised four chapters in two parts: 1) functionalization of silicon-based compounds; 2) displacement of halogen atoms from simple alkyl halides in aquous media. I Overview of functionalizations of silicon-based compounds Chapter 1 reviewed the recent development of functionlization of silicon-based compounds, according to the types of various organosilanes. II Palladium-catalyzed ipso-desilylative coupling of aryl(trimethyl)silanes with alkenes Chapter 2 focused on the recent literature regarding functionalization of aryl(trimethyl)silanes. The results on Pd-catalyzed ipso-desilylative coupling of aryl(trimethyl)silanes with electron-deficient alkenes were demonstrated and discussed. III ipso-Desilylative Acylation of Aryl(trimethyl)silanes with Acid Chlorides Chpater 3 showed the results for ipso-acylation of aryl(trimethyl)silanes with acid chlorides. The TMS group facilitated the transformation in two roles: a) increase the reactivity of electron-deficient arenes towards electrophiles; b) site selective acylation through stablization of the cation intermediate via silicon β-effect. IV Displacement of halogen atoms from simple alkyl halides in aqueous media Chapter 4 discussed a protocol of metal-free and metal-mediated displacement of halogen atoms in aqueous media. Converions of alkyl chlorides were focused and studied. |
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