Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.

154 p.

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Bibliographic Details
Main Author:	Wong, Chee Chung
Other Authors:	Liao Kin
Format:	Theses and Dissertations
Published:	2014
Subjects:	DRNTU::Engineering::Nanotechnology
Online Access:	http://hdl.handle.net/10356/57407
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Institution:	Nanyang Technological University

id	sg-ntu-dr.10356-57407
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spelling	sg-ntu-dr.10356-574072023-03-03T16:03:55Z Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications. Wong, Chee Chung Liao Kin School of Chemical and Biomedical Engineering DRNTU::Engineering::Nanotechnology 154 p. Cell adhesion and detachment are crucial components in cancer spreading, which often leads to recurrence and death. In this work, the traction force generated by cancer cells during spreading, cytoskeleton disruption, and detachment was quantified through direct electrical measurements on a novel electromechanical platform, amenable to high-throughput. This platform is based on mechanical structures, built around standard silicon processes, in which silicon nanowires (NWs) were embedded as miniature sensing elements to measure the surface stress on the mechanical structures, thus enabling to monitor of the traction forces applied by the cells to substrate during spreading. The scope of this research spans four topics; namely the electromechanical characterization of silicon NWs, and more particularly harnessing the giant piezoresistance effect in NWs, the characterization of their response as surface stress sensors, and lastly applying NWs in mechanosensing. Doctor of Philosophy (SCBE) 2014-04-07T10:29:03Z 2014-04-07T10:29:03Z 2011 2011 Thesis http://hdl.handle.net/10356/57407 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Engineering::Nanotechnology
spellingShingle	DRNTU::Engineering::Nanotechnology Wong, Chee Chung Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.
description	154 p.
author2	Liao Kin
author_facet	Liao Kin Wong, Chee Chung
format	Theses and Dissertations
author	Wong, Chee Chung
author_sort	Wong, Chee Chung
title	Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.
title_short	Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.
title_full	Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.
title_fullStr	Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.
title_full_unstemmed	Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.
title_sort	silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.
publishDate	2014
url	http://hdl.handle.net/10356/57407
_version_	1759856232562163712

Silicon nanowires for cellular mechanosensing: material electromechanical properties and applications.

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