Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.

193 p.

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Bibliographic Details
Main Author:	Zhang, Zhengwen
Other Authors:	Bjoern Holger Neu
Format:	Theses and Dissertations
Published:	2014
Subjects:	DRNTU::Science::Biological sciences::Molecular biology
Online Access:	http://hdl.handle.net/10356/57411
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Institution:	Nanyang Technological University

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spelling	sg-ntu-dr.10356-574112023-03-03T16:07:15Z Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules. Zhang, Zhengwen Bjoern Holger Neu School of Chemical and Biomedical Engineering DRNTU::Science::Biological sciences::Molecular biology 193 p. Multiple specific and non-specific forces govern cell-cell interaction. One weak non-specific interaction induced by macromolecular depletion at the cell surface has recently been suggested to play a key role in reversible RBC aggregation and in promoting RBC adhesion to other surfaces. A depletion layer develops near a surface in contact with a polymer solution if the loss of configurational entropy of the polymer is not balanced by an adsorption energy. Within this layer, the polymer concentration is lower than in the bulk phase. If a particle or cell approaches another particle in a solution containing a depleted polymer, then the difference of solvent chemical potential between the polymer-poor depletion zone and the bulk phase results in solvent displacement into the bulk phase and hence depletion interaction. Due to this interaction, an attractive force develops that tends to minimize the polymer-reduced space between particles and cells, thus resulting in flocculation or aggregation. Doctor of Philosophy (SCBE) 2014-04-07T10:29:18Z 2014-04-07T10:29:18Z 2011 2011 Thesis http://hdl.handle.net/10356/57411 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Science::Biological sciences::Molecular biology
spellingShingle	DRNTU::Science::Biological sciences::Molecular biology Zhang, Zhengwen Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.
description	193 p.
author2	Bjoern Holger Neu
author_facet	Bjoern Holger Neu Zhang, Zhengwen
format	Theses and Dissertations
author	Zhang, Zhengwen
author_sort	Zhang, Zhengwen
title	Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.
title_short	Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.
title_full	Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.
title_fullStr	Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.
title_full_unstemmed	Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.
title_sort	red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.
publishDate	2014
url	http://hdl.handle.net/10356/57411
_version_	1759857703620968448

Red blood cell adhesion to artificial surfaces in the presence of non-adsorbing macromolecules.

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