Structural studies of antimicrobial peptides by nuclear magnetic resonance (NMR) spectroscopy: mechanistic insights towards structure-function correlations.

248 p.

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Bibliographic Details
Main Author:	Rathi Saravanan
Other Authors:	Surajit Bhattacharyya
Format:	Theses and Dissertations
Published:	2014
Subjects:	DRNTU::Science::Biological sciences
Online Access:	http://hdl.handle.net/10356/57414
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Institution:	Nanyang Technological University

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spelling	sg-ntu-dr.10356-574142023-02-28T18:44:58Z Structural studies of antimicrobial peptides by nuclear magnetic resonance (NMR) spectroscopy: mechanistic insights towards structure-function correlations. Rathi Saravanan Surajit Bhattacharyya School of Biological Sciences DRNTU::Science::Biological sciences 248 p. Prolonged antibiotic misusage in human therapeutics, agriculture and veterinary, has favored the survival and spread of antibiotic resistant bacteria termed as multi drug resistant (MDR) bacteria or "superbugs". With death due to bacterial infections being ranked 4th leading cause in the U.S, treatment to such bacterial infections has become a serious concern to public health. Septicemia or commonly referred sepsis is the 10th leading cause of death in U.S with over 700,000 cases of severe sepsis estimated to occur every year. Sepsis is defined as the clinical conditions caused by host immune response to the bacterial infection characterized by systemic inflammation and coagulation. In scenario of the MDR pathogens, sepsis has emerged as the most common cause of death in intensive care units worldwide. Lipopolysaacharide (LPS) or endotoxin, the major component of the outer membrane of Gram-negative bacteria essential for bacterial survival is the key "pathogen associated molecule" causing sepsis. Endotoxin released into blood stream, during a Gram-negative bacterial infection acts as a key stimulator of host innate immune response. An uncontrolled stimulation of such response may cause overwhelmed production of inflammatory cytokines like TNF, IL-6 leading to hemorrhage and organ dysfunction termed as sepsis /septic shock. The ever increasing prevalence of "superbugs" and growing population of immune compromised patients with clinical conditions like sepsis, leukemia, hematopoietic defects etc, demands urgent need for the development of therapeutic alternatives to conventional antibiotics. Over the past few decades, a search for novel antibiotics has led to identification of cationic peptides with antimicrobial activity. Doctor of Philosophy (SBS) 2014-04-07T10:30:55Z 2014-04-07T10:30:55Z 2011 2011 Thesis http://hdl.handle.net/10356/57414 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Science::Biological sciences
spellingShingle	DRNTU::Science::Biological sciences Rathi Saravanan Structural studies of antimicrobial peptides by nuclear magnetic resonance (NMR) spectroscopy: mechanistic insights towards structure-function correlations.
description	248 p.
author2	Surajit Bhattacharyya
author_facet	Surajit Bhattacharyya Rathi Saravanan
format	Theses and Dissertations
author	Rathi Saravanan
author_sort	Rathi Saravanan
title	Structural studies of antimicrobial peptides by nuclear magnetic resonance (NMR) spectroscopy: mechanistic insights towards structure-function correlations.
title_short	Structural studies of antimicrobial peptides by nuclear magnetic resonance (NMR) spectroscopy: mechanistic insights towards structure-function correlations.
title_full	Structural studies of antimicrobial peptides by nuclear magnetic resonance (NMR) spectroscopy: mechanistic insights towards structure-function correlations.
title_fullStr	Structural studies of antimicrobial peptides by nuclear magnetic resonance (NMR) spectroscopy: mechanistic insights towards structure-function correlations.
title_full_unstemmed	Structural studies of antimicrobial peptides by nuclear magnetic resonance (NMR) spectroscopy: mechanistic insights towards structure-function correlations.
title_sort	structural studies of antimicrobial peptides by nuclear magnetic resonance (nmr) spectroscopy: mechanistic insights towards structure-function correlations.
publishDate	2014
url	http://hdl.handle.net/10356/57414
_version_	1759856604243558400

Structural studies of antimicrobial peptides by nuclear magnetic resonance (NMR) spectroscopy: mechanistic insights towards structure-function correlations.

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