Monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues

235 p.

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Bibliographic Details
Main Author:	Srivathsan Vasudevan
Other Authors:	George Chung Kit Chen
Format:	Theses and Dissertations
Published:	2014
Subjects:	DRNTU::Engineering::Electrical and electronic engineering
Online Access:	http://hdl.handle.net/10356/58089
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Institution:	Nanyang Technological University

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spelling	sg-ntu-dr.10356-580892023-07-04T15:37:52Z Monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues Srivathsan Vasudevan George Chung Kit Chen School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering 235 p. Ever since the discovery of microscopes through stacking a pair of lenses by Anthony Leeuwenhock, bio-imaging and bio-sensing have been the two important areas which rapidly developed in medical sciences research. The microscopes enabled viewing of many micro-organisms in water and this has increased the quest among researchers to explore different techniques in microscopy that can aid individual cell monitoring. Analyzing and observing individual cells is necessary for many clinical applications (e.g., detection of cancer). However, as many biological samples (e.g., cells) exhibit low contrast, the traditional bright field microscopes could not provide sufficient contrast to view these transparent samples and this led to the discovery of many microscopic techniques such as phase contrast microscope and fluorescent microscopes etc. Now, fluorescent microscopy has been an established technique for individual cell monitoring. Even though fluorescent techniques are widely used, they suffer from certain drawbacks such as cyto-toxicity due to exogenous labeling, sample preparation time and photo-bleaching effect. These disadvantages inhibit longer term continuous individual cell monitoring during assays. This thesis attempts to overcome these limitations by applying thermal lens response and imaging system, an alternative microscopic sensing technique, for real-time, non-invasive individual cell monitoring. Doctor of Philosophy (EEE) 2014-04-07T12:13:54Z 2014-04-07T12:13:54Z 2011 2011 Thesis http://hdl.handle.net/10356/58089 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Engineering::Electrical and electronic engineering
spellingShingle	DRNTU::Engineering::Electrical and electronic engineering Srivathsan Vasudevan Monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues
description	235 p.
author2	George Chung Kit Chen
author_facet	George Chung Kit Chen Srivathsan Vasudevan
format	Theses and Dissertations
author	Srivathsan Vasudevan
author_sort	Srivathsan Vasudevan
title	Monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues
title_short	Monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues
title_full	Monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues
title_fullStr	Monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues
title_full_unstemmed	Monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues
title_sort	monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues
publishDate	2014
url	http://hdl.handle.net/10356/58089
_version_	1772827701090975744

Monitoring of individual biological cells using thermal lens response and photothermal imaging technqiues

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